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Dual Variable Domain Immunoglobulin (DVD-Ig) Method

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Abstract or Description:

 Dual Variable Domain Immunoglobulin (DVD-Ig) Production Service provides immunoglobulin molecules that simultaneously target two mediators of disease by a single pharmaceutical entity. With years of experience in the field, a new type of  immunoglobulin has been created—DVD-Ig molecules of reduced potential immunogenicity, full effector functions and robust serum stability. 

The DVD-Ig is an IgG-like molecule, except that each light chain and heavy chain contains two variable domains in tandem through a short peptide linkage, instead of one variable domain. They were originally designed for treatment of complex diseases in which multiple mediators contribute to overall disease pathogenesis by distinct or redundantmechanisms. Since simultaneous blockade of multiple targets may yield better therapeutic efficacy than inhibition of a singletarget.

It includes the selection of the VD pairing from parental mAbs, the arrangement of the inner/outer orientation of the selected VDs and the determination of the amino acid sequences used to link the VDs. Besides, it is optimized DVD-Ig molecules, which have many desirable properties of a mAb, such as good expression in mammalian cells, easy purification to homogeneity using standard approaches, etc. 

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Posted By: Candy Ton on 5/22/2015 2:41:44 AM
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