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Monoclonal Antibody Epitope Mapping

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Abstract or Description:

Epitopes consist of groups of amino acids that lie close together on the protein (antigen) surface and interact with an antibody; they therefore determine antigenicity. Epitopes of proteins are usually classified as either linear (continuous) or conformational (discontinuous). Conformational epitopes are thought to form the majority of epitopes on most proteins. However, many conformational epitopes may also be recognizable as linear epitopes.

A multitude of disciplines require detailed knowledge about epitopes. Not only immunologists who have an a priori interest depend on epitope mapping protocols, but also biologists using antibodies as research tools, structural biologists studying proteinprotein interactions, clinicians investigating patients' immune responses, vaccine developers designing and testing immunogens, diagnostic labs developing and applying ELISAs, and last but not the least, biotech and pharmaceutical companies obliged to monitor the immunogenicity of novel therapeutic antibodies, proteins, and peptides, to mention only a few.

Learn more about Monoclonal Antibody Epitope Mapping.

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Posted By: Candy Ton on 8/21/2015 2:54:27 AM
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