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frasermoss
Member since: Feb 22, 2005
From: California, United States
Status: Neuroscience, Electrophysiology and Imaging Moderator
My points: 873    what's this
Name: Fraser Moss
 


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My Disciplines: not given
Areas of Interest: not given

About My Research

My research career has focused predominantly on neuronal ion channel and neurotransmittertransporter biophysics. I have extensive training in electrophysiology, fluorescence imaging,molecular biology and protein biochemistry and have employed these techniques to investigate the oligomerization, stoichiometry, trafficking and pharmacology of these elegant multimericproteins in both normal and disease states. 


The core research techniques that I use in my research are patch clamp, two-electrode voltageclamp and ion-sensitive electrode electrophysiology to record ion channel or transporter currents (e.g. CaV, hERG channels, SLC6 or SLC4 transporters) or intracellular pH when expressing the protein of interest in Xenopus oocytes or mammalian cells.   Furthermore, I established new methods to detect and quantify membrane protein oligomerization using Forster resonance energy transfer (FRET) in live cells expressing for example fluorescently tagged GAT1 GABA transportersand nicotinic acetylcholine receptors.


I am presently investigating the molecular processes modulating the function of sodium-coupled bicarbonate transporters in their roles regulating intracellular and whole-body pH and transepithelial transport.  I am also l investigating how the kidney proximal tubule senses changes in CO2 and HCO3- concentrations and transduces these changes to modulate the rate of HCO3--reabsorption during either respiratory acidosis or metabolic acidosis.

My Affiliations:

Biophysical Society, Society for Neuroscience, Case Western Reserve University, Caltech, University College London, University of Southampton

Off the bench I enjoy:

Football/Soccer

World History

Geneology

Tennis

Family

Ornithology