Scientist Solutions: International Life Science Community By Scientists For Scientists
    
Home » Forums » Antibody Based Technologies » Monoclonal & Polyclonal Antibodies » Something About Nnobody

Thanks to our sponsors who make this site possible

Something About Nnobody

RSS Feed

Would you like to save this topic, event, protocol or job so you can find it again easily?

Just click the "Save to My Lab Drawer" link and the item will be saved in the My Lab Drawer section of your bench space.

Available to members only. Please log in or register for your free account now.

Candy Ton
United States

Send PM
See Mini bio

Status: Frog Egg
Frog Egg
Topic Started by Candy Ton
on 5/15/2015 4:11 AM   
Reply to this post Go to the top of the page

Nanobody (also called domain antibody or sdAb), is an antibody fragment consisting of a single monomeric variable antibody domain, and lacking the light chain and CH1 domain of the heavy chain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDa, nanobody are much smaller than common antibodies (150–160 kDa), and even smaller than Fab fragments (~50 kDa, one light chain and half a heavy chain) and single-chain variable fragments (~25 kDa). The first nanobody were engineered from heavy-chain antibodies found in camelids; these are also called VHH fragments. That's what I leanred from here. Could anyone tell me more about it? What are the advantages? Any answers will be appreciate.


Replies
Chloehxl
United States

Send PM
See Mini bio

Status: Frog Egg
Frog Egg
Posted By Chloehxl
on 9/17/2015 6:06 AM   
Reply to this post Go to the top of the page

 I have found some relevant information on http://www.creative-biolabs.com/Nanobody-Single-Domain-Antibody.html and hope it will be helpful for you. 



As a Scientist Solutions member, you are able to register a positive vote for any topic which you believe is useful and relevant to our board or any reply which you believe is especially well worded and helpful.

By participating in the voting, you will be helping to identify the best topics & replies on the board.

You may vote once for any one post, and you may not vote for your own posts.

A post (topic or reply) will earn one "thumbs up" icon for every 10 votes received (up to 3 thumbs up), and the person who made the post will also earn two bonus points.

learn more about member points.